Gross description. Often encapsulated in mediastinum (not at other sites) Usually centered on or grow within a large spinal nerve root. May have intradural and extradural components and protrude through neural foramina of vertebral column. Plexiform tumors resemble a neural plexus. Degenerative changes are common (fat, hemorrhage, cysts Nodular plexiform neurofibromas (perineurial neurofibroma) Diffuse plexiform neurofibromas (epineurial neurofibroma) Cutaneous neurofibromas Goldblum et al.44 Subcutaneous neurofibromas Diffuse neurofibromas Localized cutaneous neurofibromas Stemmer-Rachamimov, Wolkenstein, and Ortonne (unpublished, 2008) Localized subcutaneous neurofibromas Objective To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF). Methods NF1 experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors using published and unpublished data Clinical features. Painless. 5 mm - 2 cm. Variable color: skin colored to brown to purple. Variable shape: plaques, nodules or polyps. Covered by intact skin. Suspected by pinching the nodule between the fingers and observing that the tumor is fixed within the dermis
. A benign tumor consisting of a mixture of cell types, including Schwann cells, perineurial-like cells, fibroblastic cells and entrapped axons that may be well-demarcated if intraneural or cutaneous but are diffusely infiltrative if located in extraneural soft tissu Neurofibroma is a benign nerve sheath tumor arising in the peripheral nervous system. It may be sporadic or associated with Neurofibromatosis 1. Based on the growth pattern, it is subdivided into localized, plexiform, and diffuse types. Localized Neurofibroma: It usually occurs as solitary, superficial cutaneous tumor in individuals who do not. Neurofibroma. A neurofibroma is a type of nerve tumor that forms soft bumps on or under the skin. A neurofibroma can develop within a major or minor nerve anywhere in the body. This common type of benign nerve tumor tends to form more centrally within the nerve. Sometimes it arises from several nerve bundles (plexiform neurofibroma) Neurofibroma. Diagnosis in short. Neurofibroma. H&E stain. LM. spindle cells with wavy nuclei without pleomorphism, +/-arranged in fascicles and intermixed with (wire-like) collagen (shredded carrots), moderately increased cellularity, poorly or well-circumscribed, +/-plexiform growth pattern (bag of worms), +/-mast cells (useful) Subtypes. Pathology. Diffuse cutaneous neurofibromatosis causes plaque-like elevation of the skin with thickening of the entire subcutis but without nodular masses 1,3,4. Radiographic features MRI. Diffuse cutaneous neurofibromas usually have fairly non-specific signal intensity 1: T1: iso- to hypointense to skeletal muscle; T1 C+: usually vivid contrast.
Department of Pathology Stanford University School of Medicine Stanford CA 94305-5342 . Original posting/updates:: 5/2707, 2/5/10. Superficial angiomyxoma may be indistinguishable from the cutaneous lesions of the Carney complex ; Carney complex should be considered if superficial angiomyxoma is multiple or involves the external ear ; Carney. Tumors of the Peripheral Nervous System, Atlas of Tumor Pathology, AFIP Third Series, Fascicle 24, 1999. Weiss SW, Goldblum JR, Enzinger FM. Enzinger and Weiss' soft tissue tumors . 5th ed. Philadelphia, PA: Mosby Elsevier; 200 Plexiform neurofibroma is a subtype in which the tumour grows within and irregularly expands a nerve bundle. Though large plexiform neurofibromas are thought to be diagnostic of NF1, a plexiform pattern may be seen in solitary skin lesions that are of little clinical significance. Neurofibroma pathology. Figure 1 Diagnostic Criteria. Nodule formed by prominent pacinian corpuscles with variable patterns in dermis. Single enlarged corpuscle. In skin, may be up to 2.5 mm long. Normal in skin 1-1.5 mm long. Grape-like clusters or linear groups of normal sized corpuscles. Clusters of enlarged corpuscles. Corpuscles in dermal lesions may be abnormal Using light microscopy, two previously trained oral pathologists re‐evaluated all hematoxylin and eosin slides. From a total of 15,375 cases diagnosed at a referred Oral Pathology Service, 24 cases were diagnosed as neurofibromas. Eighteen neurofibroma patients were female, with a mean age of 39.1 years
Mark Robert Wick, in Gnepp's Diagnostic Surgical Pathology of the Head and Neck (Third Edition), 2021. Neurofibromas. Solitary neurofibromas of the skin are common sporadic neoplasms, represented by nondescript soft papules or nodules measuring up to 3 cm in greatest dimension. Any skin field may be affected by solitary neurofibromas (including modified mucosae), and they are likewise seen at. We reviewed 14 neurofibromas from six patients with mild to marked nuclear atypia, with low mitotic activity in some tumors. Five tumors also had areas of increased cellularity consistent with cellular neurofibroma. Necrosis was absent. All patients were treated by conservative excision. Clinical follow-up, ranging from 8 months to 6 years.
. In this review we shall outline the pathological characteristics of the three most common malignant skin tumours with particular emphasis on aspects which influence prognosis and management Myxoid tumours of soft tissue encompass a heterogeneous group of lesions characterized by a marked abundance of extracellular mucoid (myxoid) matrix. This group of tumours demonstrate significant variability in their biological behaviour thus including tumours which are entirely harmless, tumours wi Histology of neurofollicular hamartoma. In neurofollicular hamartoma, the histopathology shows a nodular dermal spindle cell proliferation surrounded by prominent sebaceous glands. The spindle cells are plump or wavy. The sebaceous proliferation surrounds the mesenchymal component (figures 1-3). Neurofollicular hamartoma pathology
Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In Neurofibromas are often clinically, as well as histologically, indistinguishable from completely neurotized melanocytic nevi. We tested the hypothesis that immunologic markers would differentiate the perineural fibroblasts and Schwann cells of neurofibromas from the neurotized cells of melanocytic origin Sporadic cutaneous neurofibroma is the most common subtype. However, multiple neurofibromas are a key feature of NF1, in which there may be involvement of multiple cutaneous sites, peripheral nerves, and spinal roots (Figure 4). Gross examination of neurofibromas involving peripheral nerves demonstrate fusiform enlargement of the parent nerve. Pathology Outlines - Neurofibroma - genera . Cutaneous neurofibromas can occur at any time of life, although they often appear between the Underneath the dermis is the hypodermis, or subcutaneous fat layer, which provides an ongoing.. Small intratumoral cystic areas due to myxoid degeneration may be present in schwannomas. When a sudden.
Pathology Outlines Soft Tissue. Cutaneous B Cell Lymphoma Overview Pathophysiology. Lymphocytic Histiocytic And Related Cutaneous Tumors. Pathology Outlines Schwannoma. Soft Tissue WebPathology. Surgical Treatment Of Metastatic Pulmonary Soft Tissue. Cutaneous Manifestations Of Human Papilloma Virus. What Are Neurofibromas Who Gets Neurofibromas Neurofibroma •Single lesion not uncommon •Significance •Multiple lesions: Neurofibromatosis •Association between neurofibromatosis and other cancers such as melanoma, breast, basal cell carcinoma •NF1 gene relevant for many cancer Cutaneous mucinosis; Myxoid neurofibroma ; Neurothekeoma; Superficial acral fibromyxoma . Superficial angiomyxoma may be located in the perineum and external genitalia and thus confused with the first four lesions below shoulder girdle and fin spines rays lepidotrichia and the shell of tortoises and turtles In contrast to endochondral bone, dermal bone does not form to adulthood, and presents as slow - growing, pearly white or skin - colored dermal or subcutaneous papules or nodules on the face, scalp, and back, which may hemangiopericytoma is a cutaneous condition characterized by single or multiple dermal. Definition: • A benign neoplasm composed of mixture of fibroblastic and. histiocytic cells arranged in sheets of short fascicles and. accompanied by inflammatory cells, foam cells and siderophages, which may develop within subcutaneous tissue, deep soft tissue. or in parenchymal organs
Segmental enlargement of nerve. Enlarged or multiple pacinian corpuscles. Varied locations, may occur on hands. Most commonly on hands, especially fingers. Both may contain concentric onion-like proliferations. In both, perineural cells stain with EMA and residual nerve fibers stain with S100. Extraneural Perineurioma Perineurioma is an uncommon benign peripheral nerve sheath tumour composed exclusively of perineural cells.. Histology of perineurioma. Perineurioma tumour cells are spindle shaped, with long delicate cell processes amidst a collagenous stroma (figure 1). The spindle cells have pale open nuclei with a delicate chromatin pattern, an inconspicuous eosinophilic nucleolus and indistinct cell. Malignant peripheral nerve sheath tumor is the current term used by the World Health Organization for this highly aggressive tumor. MPNSTs may arise from plexiform neurofibromas, de novo or secondary to radiation therapy (, 5 7 ). At histologic analysis, the presence of mitotic figures distinguishes MPNST from otherwise typical neurofibromas
. It was first reported by Hoffman and Zurhelle in 1921. Clinically they areit is classified into two forms. The classical form is. Melanotic schwannoma (MS) is a nerve sheath tumor with a uniform composition of variably melanin-producing Schwann cells and metastatic potential. 1-44 MS is an uncommon neoplasm, accounting for less than 1% of all nerve sheath tumors, with a predilection for spinal nerve involvement. 5-12 Fewer than 200 cases have been reported. Melanotic schwannoma was first described by Millar 22 in. We analyzed three cutaneous microcystic/reticular schwannomas, occurring in two males and one female (mean age: 37.6 years). The tumors presented as a non‐painful slightly raised papule (mean: 0.7 cm) on upper arm (n = 2) and back (n = 1) Pathology Outlines - Neurofibroma - genera . ant pattern. Multiple cutaneous neurofibromas are hallmark lesions of NF1. Localized and plexiform neurofibromas of the paraspinal and sacral region are the most common abdo; Most sporadic neurofibromas do not cause pain and can be managed without surgery
Comments: Idiopathic Scrotal Calcinosis: Scrotal calcinosis is an uncommon benign condition characterized by presence of calcified nodules (usually multiple) in the scrotal skin.Most cases are thought to arise by dystrophic calcification of burnt-out cysts.Some cases may be idiopathic. It is usually seen in children and young adults.The scrotal skin contain multiple soft to hard, marble-like. . 7,29,35,42 Schwannomas and neurofibromas, which are the most common benign PNSTs, are distinguished by certain microscopic features, supported by immunohistochemistry and.
The incidence of malignant skin tumours has significantly increased in recent years. In addition to establishing a diagnosis, histopathological assessment of these tumours provide vital prognostic information that often inform decisions related to onward referral, optimal treatment and follow-up care skin pathology pathology in outline format with mouse over histology previews . Peripheral palisading at edge of lesion - root sheath differentiation (hair follicle). Contiguous with hair follicle or assoc. with trichilemmoma. DDx: Squamous cell carcinoma, clear cell variant. Basal cell carcinoma, clear cell variant. Trichilemmoma Skin Cancer begins with an incisive discussion of both normal and aging skin, and the incidences and causes of skin cancer. QUICK PATHOLOGY: Squamous Cell Papilloma of skin Next, you'll get a thorough look at all types squamous papilloma of skin pathology outlines skin cancer--followed by a section on treating cancer in various patient
Mark R. Wick, in Diagnostic Surgical Pathology of the Head and Neck (Second Edition), 2009. Neurothekeomas. Neurothekeoma is an unusual benign peripheral nerve sheath tumor that shows a reproducible tendency to arise in the skin of the head, neck, and arms in patients younger than 30 years of age. It presents as a nondescript, soft, tan nodule. A nevus (plural nevi) is a mole on the skin that can occur on any part of the body. A Neurotized Nevus is a type of mole. In this type, the melanocytes are in the dermis. With time, there is fibrosis around these melanocytes resulting in a benign Neurotized Nevus. A diagnosis is not made clinically by examining the patient, since the Neurotized.
Trichofolliculoma presents as a small, solitary flesh-coloured or whitish nodule that occurs most often on the face around the nose region. Centrally, there is a pore which sometimes may contain numerous hairs. Histology of trichofolliculoma. In trichofolliculoma, sections show numerous small follicles radiating from a central larger follicle.The hairs are surrounded by a well circumscribed. Plexiform neurofibroma is considered an uncommon skin tumor. The involvement of the genitourinary tract or the lower limb is rare, with bladder, upper urinary tract and genital involvement reported in decreasing order of frequency. The management of patients with plexiform neurofibroma is not well defined and aiming mostly at controlling symptoms
Neurofibromatosis type 1: NF1, a genetic disorder characterized by a number of remarkable skin findings including multiple café au lait spots, multiple benign tumors on the skin, plexiform neurofibromas, and freckles in the armpit and groin. In NF1 there is an increased risk of scoliosis, optic gliomas (benign tumors on the optic nerve. Pathology Outlines - Chondroid syringom . Srinivasan R, Rajwanshi A, Padmanabhan V, Dey P. Fine needle aspiration cytology of chondroid syringoma and syringocystdnoma syringocystadenoma pipilliferum. A report of two cases. Acta Cytol 1993;37:535-8 Chondroid syringoma is a rare skin adnexal tumor Seborrheic keratosis. Seborrheic keratosis is a common benign skin lesion that affects middle-aged and older individuals. They are well-demarcated warty plaques that may vary in size, degree of pigmentation, and shape of surface which may be greasy.Histologically, seborrheic keratosis is a lesion above the skin surface, showing acanthotic proliferation of basaloid cells with various degrees. Plexiform neurofibromas The second most common Nf1 complication, after learning difficulties, is plexiform neurofibroma (PNF). The plexiform neurofibromas differ from focal cutaneous neurofibromas, that originate from many nerve bundles, and tend to grow along the length of the nerve
Diagnosis Treatment Research. Pathology Outlines Schwannoma. Soft Tissue Tumors An Overview. Neoplasm Wikipedia. Cutaneous B Cell Lymphoma Overview Pathophysiology. Homo Sapiens Diseases Cutaneous Apparatus And what are neurofibromas who gets neurofibromas june 24th, 2018 - what are neurofibromas neurofibromas ar WebPathology is a free educational resource with 11151 high quality pathology images of benign and malignant neoplasms and related entities. Cutaneous Leiomyoma. Cutaneous Leiomyoma. Cutaneous Leiomyoma. Cutaneous Leiomyoma. Neurofibroma. Neurofibroma. Neurofibroma. Neurofibroma. Neurofibroma. 35 slides. May 201
Introduction. Neurofibromatosis type 1 (NF1) is a common autosomal dominant tumor predisposition syndrome affecting approximately 1 in 3,000 individuals at birth 1, 2.NF1 is associated with a number of clinical manifestations including café-au-lait macules, axillary/inguinal freckling, Lisch nodules, skeletal abnormalities, and learning disabilities Cutaneous soft tissue tumors with epithelioid features present a diagnostic challenge given that many entities in this category are rare, and they show morphologic overlap with significantly more.
Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+.FXIIIa plays a key role in fibrin stabilization, and defective fibrin stabilization is demonstrable as a result of severe haemorrhagic manifestations of congenital FXIII deficiency, which is an. Clinical signs. oval or digitate patches, 2 - 6 cm in diameter. surface reddish or yellowish. pseudoatrophic wrinkling and slight pityriasiform scaling. location: lateral parts of the trunk. exceptionally good prognosis. variants: small plaque parapsoriasis. dermatosis digitata (small, reddish patches on lateral sides of the trunk
Fibroepithelial polyp. H&E stain. LM. On a stalk / epithelium on three sides, benign epidermis, fibrous core, +/-inflammation. LM DDx. Regressing melanocytic lesions (esp. intradermal melanocytic nevus ), pedunculated seborrheic keratosis, nevus lipomatosus superficialis, neurofibroma. Gross. raised skin-coloured lesion Introduction. Following the previously published first part of Dermatopathology 101 - Inflammatory skin diseases 1, the second part focuses on skin tumors.This second article is aimed at dermatology residents as well as board-certified specialists who would like to refresh their basic dermatopathology knowledge Neurofibroma Neurofibroma, Plexiform Neurofibromatosis 1 Neurofibrosarcoma Nerve Sheath Neoplasms Neurofibromatoses Peripheral Nervous System Neoplasms Cafe-au-Lait Spots Neurilemmoma Neuroma Vagus Nerve Diseases Mandibular Neoplasms Gingival Neoplasms Spinal Cord Neoplasms Lipoma Neurofibromatosis 2 Soft Tissue Neoplasms Brain Neoplasms Glioma.
Neurofibromatosis is associated with cutaneous melanin pigmentation, but an association with ordinary melanocytic nevi has not been described. This retrospective case‐control study was designed to see if neurofibromas in patients with Neurofibromatosis, Type I (NF‐1) differ from sporadic neurofibromas (SN) in their incidence of associated melanocytic nevi and other histologic features. Infantile myofibromatosis. Neurofilament. Neurofibroma. Neuro-specific enolase. Merkel cell carcinoma. Non-aqueous alcoholic eosin stain (NAES) Pseudogout. Oil red O. Sebaceous carcinoma Plexiform neurofibromas are a common complication of neurofibromatosis. Diagnosed through physical examinations. However, the full extent of the lesion is best seen by MRI scans. Approximately 75% of patients who undergo a complete removal of the tumor — without causing significant neurologic impairment or dysfunction — are cured Desmoid-type fibromatosis. H&E stain. LM. sweeping fascicles/bundles, spindle cells with small slender nuclei, solid dark eosinophilic cytoplasm, +/-mitoses, long thin-walled vessels - parallel to one another. Subtypes. Intra and extra-abdominal types are sometimes considered separately. LM DDx. hypertrophic scar, gastrointestinal stromal. Hybrid Schwannoma / Neurofibroma are overrepresented in hereditary conditions. DDx: Meningioma. Intranodal palisaded myofibroblastoma - if surrounded by a rim of lymphoid tissue, i.e. intranodal. Leiomyoma. Gastrointestinal stromal tumour. MPNST - schwannoma with ancient change has no significant mitotic activity. Neurofibroma
We report a cutaneous lipomatous neurofibroma on the skin of the left-side parietal area of approximately 9 months' duration in a 67-year-old woman. The regular distribution of adipose tissue throughout the lesion suggested that fat was an integral part of the tumor, not a metaplastic or degenerative process Background: Skin adnexal neoplasms are relatively rare and thus uncommonly encountered in routine pathology practice.Aims: The present study was conducted with the aim to diagnose various skin adnexal tumors on fine-needle aspiration cytology (FNAC) followed by confirmation on histopathology and immunohistochemistry of the excised tumor.Materials and Methods: A total of 11 cases of superficial. Selumetinib (Koselugo) is a treatment for plexiform neurofibroma in children. Clinical trials of similar drugs are currently ongoing for children and adults. Surgery and other procedures. Your doctor might recommend surgery or other procedures to treat severe symptoms or complications of neurofibromatosis. Surgery to remove tumors
Dermatofibroma. H&E stain. LM. prominent fibrous bundles - especially at the edge of the lesion (collagen-trapping), loss of adnexal structures, +/-dirty fingers ( acanthosis, basal keratinocyte hyperpigmentation) Subtypes. cellular, deep penetrating, lipidized, epithelioid cell histiocytoma, fibrotic, aneurysmal, granular cell. Neurofibromatosis, either of two hereditary disorders characterized by distinctive skin lesions and by benign, progressively enlarging tumours of the nervous system. Neurofibromatosis type 1, also known as von Recklinghausen's disease, is much the more common of the two disorders and is present in about one of every 3,000 live births.This type is characterized by the presence of café-au. In addition to large plexiform neurofibromas (pNF), NF1 patients are frequently disfigured by cutaneous neurofibromas (cNF) and are often afflicted with chronic pain and itch even from seemingly normal skin areas. Both pNFs and cNF consist primarily of benign hyperproliferating nonmyelinating Schwann cells (nSC). While pNF clearly arise within deep nerves and plexuses, the role of cutaneous. MAP/ERK kinase 1 and 2 (MEK 1/2) inhibitors (MEKi) are investigated in several trials to treat lesions that arise from pathogenic variants of the Neurofibromatosis type 1 and type 2 genes (NF1, NF2). These trials showed that MEKi are capable to shrink volume of low grade gliomas and plexiform neurofibromas in NF1. Targeting other lesions being associated with a high morbidity in NF1 seems to.
Neurofibromas are the hallmark lesions in Neurofibromatosis 1 (NF1); these tumors are classified as cutaneous, subcutaneous and plexiform. In contrast to cutaneous and subcutaneous neurofibromas, plexiform neurofibromas can grow quickly and progress to malignancy. Curcumin, a turmeric-derived polyphenol, has been shown to interact with several molecular targets implicated in carcinogenesis Café au lait hypermigmented skin spots multiple benign neurofibromas benign from PATHOLOGY Pathology at Lake Erie College of Osteopathic Medicin BENIGN AND LOW-GRADE SPINDLE CELL TUMORS 6.1 Fibromas 6.2 Elastofibroma 6.3 Fibromatosis 6.4 Neurofibroma 6.5 Schwannoma 6.6 Perineurioma 6.7 Nodular Fasciitis 6.8 Additional Variants of Fasciitis 6.9 Angiomyofibroblastoma 6.10 Cellular Angiofibroma 6.11 Myofibroblastoma 6.12 Gastrointestinal Stromal Tumor 6.13 Leiomyoma 6.14 Myofibroma and Myofibromatosis 6.15 Solitary Fibrous Tumor 6.16 Low. Received in the surgical pathology lab was an above elbow amputation consisting of a 30.0 cm long distal arm, an attached hand measuring 17.0 cm in maximum length., and a 4.5 cm long exposed humerus. The specimen is covered by grossly unremarkable skin, with a palpable mass in the mid-portion of the forearm
Myxoid neurofibromas exhibit wavy nuclei and S-100 positivity that can help distinguish this lesion; neurothekeomas are superficial lesions that have a characteristic lobular pattern of growth; some exhibit S-100 protein positivity. 16, 17 The distinction between LGFMS and low grade myxofibrosarcoma, considered the equivalent of the low grade. Pathology Outlines - Epidermolytic hyperkeratosi . The histological changes observed in the nails are very similar to those of affected skin: hyperkeratosis, hypergranulosis, irregular epidermal hyperplasia, a lichenoid infiltrate with the formation of Civatte bodies, vacuolar degeneration of the basement membrane, and pigmentary incontinenc
cartilage - see chondro-osseous tumours. Syndromes. Ollier disease, Maffucci syndrome, metachondromatosis. Prognosis. benign. Chondroma is a benign tumour of cartilage. It is in the chondro-osseous tumours group of soft tissue tumours Cutaneous Spindle Cell Tumors. The differential diagnosis of atypical spindle cell neoplasms on sun-damaged skin includes atypical fibroxanthoma, spindle cell or desmoplastic melanoma, spindle cell squamous cell carcinoma, and leiomyosarcoma. This is a not-infrequent challenging differential in skin tumor pathology Microscopic pathology image of Skin showing a neurotized melanocytic nevus. The topic Neurotized Melanocytic Nevus you are seeking is a synonym, D., Shayanfar, N., & Soltanzadeh, P. (2006). Giant congenital melanocytic nevus with neurofibroma‐like changes and spina bifida occulta. International journal of dermatology, 45(11), 1347-1350
dase) by mesenchymal tumors of the skin. Anticancer Res 20(5B): 3539-3544, Sep-Oct 2000. Miettinen M: Diagnostic soft tissue pathology. Churchill-Livingstone, New York, 2003, page 56. Horenstein M et al: Indeterminate fibrohistiocytic lesions of the skin. Is there a spectrum between dermatofibroma and dermatofibrosarcoma protuberans Hemangioendothelioma, also known as hemangiosarcoma, is a rare, malignant, vascular tumor with endothelial differentiation that is more common in soft tissues than bone. The tumor typically presents in patients between ages 30 and 40 with regional pain. Diagnosis is made with biopsy and histology showing angiocentric growth expanding the vessel.
Bednar tumour, first described by Bednar in 1957, is a pigmented variant of dermatofibrosarcoma protuberans (DFSP).It is a rare entity, constituting1 to 5% of all DFSPs, which in turn, represent 0.1% of skin malignancies. It differs from DFSP by the presence of dendritic cells containing melanin, interspersed between the fusiform cells. Desmoplastic melanoma is a type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin. Desmoplastic melanoma is a rare form of the disease that accounts for around 4 percent of all skin melanomas multiple neurofibromas, and also entails spinal and cranio-facial skeletal abnormalities. There is a definite although relatively small (1 - 4%) risk of malignant peripheral nerve sheath tumor arising in neurofibroma and risk of central nervous system tumors, especially gliomas . GISTs have been sporadically diagnosed in patient Nerve sheath myxoma (NSM) is a rare, benign tumor of predominantly cutaneous location. They usually arise from small cutaneous nerves in the head, neck, and extremities, but exceptionally they arise from spinal nerve roots. Only three cases of intraspinal NSM have been reported. Herein is describe two additional cases of spinal NSM. The patients were 64‐year‐old and 31‐year‐old men who.